Stable at broad pH ranges and high temperatures
AFFINIMIP¢ç SPE phases are highly cross-linked polymers that maintain stability when exposed to organic solvents. They are stable at high temperatures, and can be used over broad pH ranges, without loss of selectivity. They can be stored at room temperatures for prolonged periods of times (several years). This is extremely advantageous over immunoaffinity based products.
Reduction of ion suppression
Ion suppression is a problematic phenomenon that occurs when analyzing trace levels of analyte(s) in complex matrices with hyphenated techniques such as LC-MS-MS (Liquid Chromatography - tandem Mass Spectrometry). It is caused by the co-elution of matrix components with analyte(s) of interest and negatively affects several analytical figures of merit such as detection capability, precision and accuracy. Therefore, a perfect sample cleanup during sample preparation is critical. Thanks to the selectivity of AFFINIMIP¢ç technology, ion suppression is reduced compared to more conventional SPE phases.